GSL's Targeted Protein Panels deliver high-confidence, quantitative measurement of disease-relevant proteins using advanced mass spectrometry workflows. Designed to support discovery, translation, and clinical development, our panels provide deep insight into lysosomal biology, neurodegeneration, and rare disease mechanisms, all with the scientific rigour and reliability our partners expect from GSL.
LYSOSOMAL OMICS: A FOCUSED PROTEIN STRATEGY
The GSL Lysosomal Omics Protein Panel is a curated suite of enzymes, activators, and membrane proteins central to lysosomal function and dysfunction. Targets are selected based on strong biological relevance to neurodegeneration, lysosomal storage disorders, and inflammatory processes.
OUR INDIVIDUAL PANELS
PROTEASES
Cathepsin B
Gene:CTSB
Cathepsin C
Gene:CTSC
Cathepsin D
Gene:CTSD
Cathepsin F
Gene:CTSF
Cathepsin H
Gene:CTSH
Cathepsin K
Gene:CTSK
Cathepsin L
Gene:CTSL
Cathepsin S
Gene:CTSS
Cathepsin O(Cathepsin O/CTSO)
Gene:CTS0
Cathepsin V
Gene:CTSV
Cathepsin Z
Gene:CTSZ
TripeptidylPeptidase 1
Gene:TPP1
TripeptidylPeptidase 2
Gene:TPP2
DipeptidylPeptidase 7
Gene:DPP7
Pro-XCarboxypeptidase
Gene:PRCP
GLYCOSIDASES
AlphaGalactosidase A
Gene:GLA
BetaGlucocerebrosidase
Gene:GBA
BetaGalactosidase
Gene:GLB1
AlphaMannosidase
Gene:MAN2B1
BetaHexosaminidase A
Gene:HEXB
BetaHexosaminidase B
Gene:HEXB
BetaMannosidase
Gene:MANBA
Neuraminidase 1
Gene:NEU1
N-Acetylgalactosamine-6-Sulfatase
Gene:GALNS
N-Acetylglucosamine-1-Phosphotransferase
Gene:GNPTAB
SULFATASES
Arylsulfatase A
Gene:ARSA
Arylsulfatase B
Gene:ARSB
Arylsulfatase C
Gene:ARSC
Arylsulfatase D
Gene:ARSD
Arylsulfatase E
Gene:ARSE
Arylsulfatase F
Gene:ARSF
Arylsulfatase G
Gene:ARSG
Steroid Sulfatase
Gene:STS
LIPASES
Lysosomal Acid Lipase
Gene:LIPA
Acid Ceramidase
Gene:ASAH1
Phospholipase A2 Group XV
Gene:PLA2G15
Sphingomyelin Phosphodiesterase 1
Gene:SMPD1
Sphingomyelin Phosphodiesterase 2
Gene:SMPD2
MEMBRANE PROTEINS
Lysosomal Associated MembraneProtein 1
Gene:LAMP1
Lysosomal Associated MembraneProtein 2
Gene:LAMP2
Lysosomal Associated MembraneProtein 3
Gene:LAMP3
ACTIVATOR OR ACCESSORY
Prosaposin
Gene:PSAP
GM2 Activator Protein
Gene:GM2A
Lysosomal Protective Protein
Gene:CTSA
ACTIVATOR OR ACCESSORY
(IN DEVELOPMENT)
Saposin A
Gene:PSAP (processed)
Saposin B
Gene:PSAP (processed)
Saposin C
Gene:PSAP (processed)
Saposin D
Gene:PSAP (processed)
ACIDIFICATION MACHINERY
V-type Proton ATPase Subunit A
Gene:ATP6V1A
V-type Proton ATPase Subunit B
Gene:ATP6V1B2
V-type Proton ATPase Subunit C
Gene:ATP6V1C1
V-type Proton ATPase Subunit D
Gene:ATP6V1D
V-type Proton ATPase Subunit E
Gene:ATP6V1E1
V-type Proton ATPase Subunit G
Gene:ATP6V1G1
V-type Proton ATPase Subunit H
Gene:ATP6V1H
